PRODUCTS
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Co Cap™ A mRNA cap analog
Consistent mRNA capping for reliable results
Co Cap™ A is a high-performance mRNA co-transcriptional cap analog designed to improve the stability and translational efficiency of mRNA molecules. By protecting transcripts from 5’–3’ exonuclease degradation, it helps ensure stronger protein expression and more reliable results across research, development, and manufacturing applications.
KEY CHARACTERISTICS
Reliable, Scalable, and Flexible mRNA Capping
Co Cap™ A is designed to deliver consistent performance for mRNA co-transcriptional capping, whether for research, process development, or early clinical applications. Its versatile format, scalable supply, and high-quality standards make it suitable for a wide range of RNA programmes.
Scalable supply from milligrams to kilograms with rapid turnaround
5’ Cap 1 mRNA suitable for direct use in in vitro transcription
Custom options including sodium salt form and other cap variants
Flexible packaging available off-the-shelf or in bulk as powder or solution
Available in research-grade and GMP-grade quality
USE CASES
For Versatile Research And Development
In vitro transcription capping
Add Co Cap™ A directly to your IVT reaction for efficient co-transcriptional 5′ capping, removing the need for a separate enzymatic step.
Vaccine & therapeutic mRNA
Produce capped mRNA with improved stability and translational efficiency, from research through early clinical development.
Process development & cost reduction
Lower the per-batch cost of capping during development and scale-up, supporting parallel candidate screening.
Scale-up to supply
Move from research- grade to GMP-grade Co-Cap™ A as your programme advances, with scalable supply from milligrams to kilograms.
QUALITY & COMPLIANCE
Cost-Efficient Capping for Scalable Development
Co Cap™ A is cost-effective and can support parallel development of your candidates, relieving your budget of Cap cost. Our reagent is available in two grades (research and GMP), and will be able to carry your research and development all the way to commercial manufacturing
- Consistent Quality – Co Cap™ A’s proprietary manufacturing process ensures batch-to-batch consistency and high purity.
- Increase Efficacy – The use of Co Cap™ A results in mRNA molecules with a higher level of stability, leading to increased efficacy of mRNA-based therapeutics.
- Broad Applications – Co Cap™ A is compatible with a wide range of mRNA-based therapeutic applications, including vaccines, gene therapies, and cancer treatments.
MANUFACTURING
Produced under controlled and documented systems
Co Cap™ A is manufactured under controlled, documented processes with defined raw materials and quality review before release. Each batch is tested for identity and purity and supplied with a Certificate of Analysis, ensuring batch-to- batch consistency and traceability.
TECHNICAL SUPPORT
Expert Guidance at Every Stage
Our scientific team provides hands-on support for experimental design, construct optimisation, and troubleshooting.
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CUSTOMISATION
Tailored Solutions to Meet Your Needs
We offer bespoke RNA solutions, including sequence optimisation, formulation adjustments, and scale-specific production, to match your programme requirements.
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FAQS
Your Questions Answered
Our FAQ section addresses the most common technical and compliance queries, providing clarity on our capabilities, processes, and quality systems.
Yes, our facilities produce GMP-aligned and clinical-grade mRNA and plasmid DNA suitable for early-phase trials.
We follow GMP-aligned processes, robust documentation, and quality oversight to meet regulatory expectations and support submissions.
We offer flexible production from milligram-scale research material to multi-gram clinical-grade batches.
Yes, our in-house analytical team supports identity, purity, impurity profiling, and stability testing across all projects.
Absolutely. Our team develops reproducible processes for smooth transition from research-scale to GMP-aligned clinical production.
Other Products
RNA Development & Manufacturing
Southern RNA offers plasmid DNA and mRNA services, combining flexible manufacturing with analytics. We support scalable, high-quality nucleic acid production.
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